Polyethylene Glycol (PEG-3350, Colyte) Poisoning due to Intra-Peritoneal Leakage in an Elderly Patient.
10.4266/kjccm.2015.30.1.56
- Author:
Jae Hee CHUNG
;
Seok Chan KIM
;
Jun Gi KIM
- Publication Type:Case Report
- Keywords:
leak;
poisoning;
polyethylene glycols
- MeSH:
Absorption;
Acid-Base Equilibrium;
Acidosis;
Aged*;
Colonoscopy;
Humans;
Hypernatremia;
Metabolism;
Molecular Weight;
Peritoneal Cavity;
Poisoning*;
Polyethylene Glycols*;
Renal Replacement Therapy;
Therapeutic Irrigation
- From:Korean Journal of Critical Care Medicine
2015;30(1):56-60
- CountryRepublic of Korea
- Language:English
-
Abstract:
Polyethylene glycol (PEG)-3350 is the most frequently used lavage solution for bowel cleansing prior to colonoscopy or elective surgery because its large molecular weight means that it is poorly absorbed. However, if it leaks into the peritoneal cavity, complications may arise. Few published studies have assessed the absorption, distribution, metabolism and excretion of PEG. Moreover, no published clinical data regarding complications due to the intra-peritoneal leakage of PEG-3350 could be found. We report on an elderly patient who developed the poisoning caused by leaking of PEG-3350 during bowel preparation. It resulted in severe metabolic acidosis, hypernatremia, hyperosmolality and a high anion gap, but it was effectively treated with early continuous renal replacement therapy after surgery.
