The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function.

Author: Gary A KORETZKY ¹
Author Information

1. Department of Pathology and Laboratory Medicine and Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA. Koretzky@mail.med.upenn.edu
Publication Type:Review
Keywords: SH2 domain-containing leukocyte phosphoprotein of 76 kDa; signal transduction; T cells; integrins; immunoreceptors; adapter proteins
MeSH: Explosions; Integrins; Leukocytes; Proteins; Signal Transduction; T-Lymphocytes
From:Immune Network 2009;9(3):75-83
CountryRepublic of Korea
Language:English
Abstract: Recent years have seen an explosion of new knowledge defining the molecular events that are critical for development and activation of immune cells. Much of this new information has come from a careful molecular dissection of key signal transduction pathways that are initiated when immune cell receptors are engaged. In addition to the receptors themselves and critical effector molecules, these signaling pathways depend on adapters, proteins that have no intrinsic effector function but serve instead as scaffolds to nucleate multimolecular complexes. This review summarizes some of what has been learned about one such adapter protein, SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76), and how it regulates and integrates signals after engagement of immunoreceptors and integrins on various immune cell lineages.