A Case of Methotrexate-induced Bullous Acral Erythema.
- Author:
Ye Won HAN
1
;
Kyung Ho LEE
;
Chul Jong PARK
Author Information
- Publication Type:Case Report
- Keywords: Methotrexate; Bullous acral erythema
- MeSH: Aged; Cytarabine; Diagnosis, Differential; Erythema*; Graft vs Host Disease; Hand-Foot Syndrome; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stevens-Johnson Syndrome
- From:Annals of Dermatology 2007;19(4):160-162
- CountryRepublic of Korea
- Language:English
- Abstract: Chemotherapy-induced acral erythema (CIAE) is a toxic reaction to a number of different chemotherapeutic agents, and causes symmetrical, well-demarcated, painful erythema on the palms and soles which is self-limiting. CIAE with bullous reaction in relation to methotrexate has been reported, but it is more commonly associated with cytosine arabinoside. The differential diagnosis of this condition from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. In this paper, we report the case of a 65-year-old man who developed bullous acral erythema after the administration of high-dose methotrexate for the treatment of Non-Hodgkin's lymphoma.
