The Association with Amniotic Fluid Interleukin-6 and Histologic Chorioamnionitis in Patients with Preterm Labor and Intact Membranes.
- Author:
Young Ju KIM
1
;
Mi Hye PARK
;
Jung Ja AHN
;
Bock Hi WOO
;
Wha Soon CHUNG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.
- Publication Type:Original Article
- Keywords:
Amniotic fluid;
Interleukin-6;
Perinatal morbidity;
Histologic chorioamnionitis
- MeSH:
Amniotic Fluid*;
Chorioamnionitis*;
Diagnosis;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Interleukin-6*;
Membranes*;
Obstetric Labor, Premature*;
Pregnancy;
Sensitivity and Specificity
- From:Korean Journal of Obstetrics and Gynecology
1997;40(2):275-280
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Our purpose was to determine whether amniotic amniotic fluid concentrations of interleukin-6 are valuable in the prediction of histologic chorioamnionitis and in the prediction of perinatal morbidity. STUDY DESIGN: The relation among amniotic fluid imterleukin-6, histologic chorioamnionitis, and perinatal outcome was examined in patients with preterm labor and intact membranes. Interleukin-6 was determined by ELISA method. RESULTS: Patients with histologic chorioamnionitis had significantly higher amniotic fluld interleukin-6 concentrations than patient without histologic chrioamnionitis. Also, patient with histologic chorioamnioitis had significantly higher perinatal morbidity rate than patient without histologic chorioamnionitis. An ammiotic fluld interlerkin-6 concentration had a sensitivity of 75% and a specificity of 62.5% in the diagnosis of preterm delivery. CONCLUSION: Amniotic fluld interleukin-6 is a sensitive test for the prediction of histologic chorioamnionitis and of perinatal morbidity.
