Antenatal Cytogenetic Analysis Using Cordocentesis.
- Author:
Jong Kwan JUN
1
;
Kyo Hoon PARK
;
Bo Hyun YOON
;
Shin Yong MOON
;
Hee Chul SYN
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cytogenetic analysis;
Karyotyping;
Cordocentesis;
Congenital anomaly
- MeSH:
Abnormal Karyotype;
Bradycardia;
Chromosome Aberrations;
Cordocentesis*;
Cytogenetic Analysis*;
Cytogenetics*;
Female;
Fetal Blood;
Fetal Death;
Fetus;
Karyotyping;
Lost to Follow-Up;
Lymphocytes;
Pregnancy;
Pregnancy Outcome;
Stillbirth
- From:Korean Journal of Obstetrics and Gynecology
1997;40(2):286-299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pure fetal blood was obtained by cordocentesis or cardiocentesis guided by USG in 160 fetuses at 15 to 37 weeks' gestation. Only 1 case failed to obtain cytogenetic result. Cytogenetic analysis of fetal lymphocytes yielded results within 5 days. Chromosomal abnormalities were found in 21 of 159 fetuses(13.2%). Abnormal karyotypes were found in 19 of 118 fetuses(16.1%) with structural malformations~8.6%(7/81) affected by isolated malformations vs. 32.4%(12/37) affected by multiple malformations. There were 12 cases of bradycardia which was the most common nonfatal complication (7.4%). One fetal death was recorded. Pregnancy outcome is as follows: 17 cases of stillbirth, 38 cases of termination of pregnancy, 15 cases of neonatal death, 5 cases of infantile death, 55 cases of living babies, and 29 cases lost to follow-up. It is concluded that rapid karyotyping by cordocentesis is advisable as effective method in fetuses at high risk of a chromosomal aberration, especially in advanced gestations.
