A case of mixed connective tissue disease presenting initially with Raynaud's phenomenon.
10.3345/kjp.2008.51.8.886
- Author:
Soo Young KIM
1
;
Young Seok CHOI
;
Young Ok KIM
;
Young Jong WOO
Author Information
1. Department of Pediatrics, School of Medicine, Chonnam National University, Gwangju, Korea. ik052@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Mixed connective tissue disease;
Raynaud's phenomenon;
Antibody to ribonucleoprotein
- MeSH:
Adult;
Alopecia;
Antibodies;
Arthritis;
Arthritis, Rheumatoid;
Child;
Dermatomyositis;
Fingers;
Follow-Up Studies;
Hand;
Humans;
Mixed Connective Tissue Disease;
Scleroderma, Systemic;
Ulcer
- From:Korean Journal of Pediatrics
2008;51(8):886-891
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud's phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.
