Association of Antiphospholipid Antibodies and Thrombosis in Patients with Systemic Lupus Erythematosus.
- Author:
Sung Hwan PARK
1
;
Bum Soon CHOI
;
Young Suk CHO
;
Hyung In YANG
;
Yeon Sik HONG
;
Sang Heon LEE
;
Chul Soo CHO
;
Ho Youn KIM
Author Information
1. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Systemic lups erythematosus;
thrombosis;
anticardiolipin antibodies;
lupus anticoagulant
- MeSH:
Antibodies;
Antibodies, Anticardiolipin;
Antibodies, Antiphospholipid*;
Diagnosis;
Enzyme-Linked Immunosorbent Assay;
Humans;
Immunoglobulin A;
Immunoglobulin G;
Immunoglobulin M;
Kaolin;
Lupus Coagulation Inhibitor;
Lupus Erythematosus, Systemic*;
Prevalence;
Thrombosis*
- From:The Journal of the Korean Rheumatism Association
1996;3(1):41-49
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the association of antiphosphoilpid antibodies with thrombosis and to evaluate the clinical usefulness of anticardiolipin isotypes measurement in patients with systemic lupus erythematosus (SLE). METHODS: We examined the prevalence of IgG, IgM and IgA anticardiolipin antibod (aCL) isotypes measured by ELISA assay and lupus anticoagulant (LA) measured by kaolin clotting time in 158 patients. RESULTS: The prevalence of aCL and their IgM and IgA isotypes were 43.7%, 24. 7%, 17. 7% and 17. 1% respectively. The prevalence of LA was 7.8%. The presence of IgG aCL (81,81%, odds ratio(OR)=17.55, p (0.001) and LA (45.45%, OR=16.67, p ( 0. 001) were significantly associated with thrombosis. A regression analysis showed that IgG aCL (OR=13.62, p=0.002) and LA (OR=10.59, p=0. 002) were also associated with thrombosis. CONCLUSION: Our results suggest that the detection and serial monitoring of IgG aCL is a useful tool for diagnosis of thrombotic complication due to antiphosholipid antibodies in SLE.
