A Case of Mycobacterium chelonae Infection with Foreign Body Granuloma after Injection of Filler.
- Author:
Woon Kyong CHUNG
1
;
Gyeong Hun PARK
;
Sung Eun CHANG
;
Mi Woo LEE
;
Jee Ho CHOI
;
Kee Chan MOON
;
Jai Kyoung KOH
Author Information
1. Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 1052_hihi@hanmail.net
- Publication Type:Case Report
- Keywords:
Atypical mycobacterial infection;
Filler;
Foreign body granuloma;
Mycobacterium chelonae
- MeSH:
Cheek;
Cheese;
Clarithromycin;
Edema;
Erythema;
Female;
Foreign Bodies;
Giant Cells;
Granuloma, Foreign-Body;
Histiocytes;
Humans;
Inflammation;
Lymphocytes;
Middle Aged;
Mycobacterium;
Mycobacterium chelonae;
Necrosis
- From:Korean Journal of Dermatology
2008;46(11):1521-1525
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although injectable soft-tissue augmentation materials are extremely well-tolerated, undesirable effects sometimes occur. Whereas minor adverse events such as erythema, edema or bruising are generally reversible, the formation of foreign body granuloma, atypical mycobacterial infections or tissue necrosis may cause serious irreversible damages and disfigurement. We present here the case of a 50-year-old woman with an indurated painful nodule and patch on the right cheek, and this occurred after an unlicensed nonspecialist injected filler of unknown ingredients. The histopathologic findings showed granulomatous inflammation composed of lymphocytes, histiocytes and multinucleated giant cells with a Swiss cheese appearance. Although any acid-fast bacilli were not observed on Ziehl-Neelsen staining, the mycobacterial culture demonstrated an ivory-colored wet colony that was identified as M. chelonae by polymerase chain reaction-restriction fragment length polymorphism. The patient was treated with 1 g of clarithromycin for seven weeks, and the lesion improved considerably.
