The Effects of 0.45% and 0.9% Saline Solutions on Serum Sodium Concentrations in Chronic Renal Failure Patients.
10.4097/kjae.2003.44.4.462
- Author:
Min Ah KWON
1
;
Gaab Su KIM
;
Jung Kil HONG
;
Hyun Sung JO
;
Jin Kyung KIM
;
Mi Kyung YANG
;
Byung Dal LEE
Author Information
1. Department of Anesthesiology, SungKyunKwan University School of Medicine, Seoul, Korea. gskim@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Chronic renal failure;
Na K ATPase;
sodium
- MeSH:
Humans;
Kidney Failure, Chronic*;
Kidney Transplantation;
Potassium;
Reference Values;
Renal Veins;
Sodium Chloride;
Sodium*
- From:Korean Journal of Anesthesiology
2003;44(4):462-468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGORUND: To choose optimal potassium free solutions in chronic renal failure patients, we studied the effects of 0.45% or 0.9% saline solutions on the serum sodium concentrations of patients undergoing kidney transplantation surgery. METHODS: Sixty two patients, ASA physical status iii iV, undergoing kidney transplantation surgery, were allocated to receive either 0.45% saline (n = 26) or 0.9% saline solutions (n = 36). The patients received 2 L of 0.45% or 0.9% saline solutions with a CVP of 10 mmHg prior to a renal vein anastomosis. Serum sodium and potassium concentrations were measured before (Na0, K0) and after the administration of 2 L of 0.45% or 0.9% saline solutions (Na2, K2), respectively. RESULTS: Serum sodium concentrations decreased after the administration of 0.45% saline solutions, and after administrating 2 L of 0.9% saline, the serum sodium concentrations increased in patients with baseline serum sodium concentrations lower than 136 mEq/L. When we administered 0.9% saline, which had a sodium concentration lower than the serum sodium concentration, the serum sodium concentration measured after 2 L of 0.9% saline infusion proportionally decreased in patients with baseline serum sodium concentration greater than 136 mEq/L (P<0.001). CONCLUSiONS: For ideal fluid selection in chronic renal failure patients, this study suggests a 0.45% saline solution for chronic renal failure patients with a baseline serum sodium concentration below the normal range and a 0.9% saline solution for patients with a baseline sodium concentration within the normal range.
