Cutaneous Rosai-Dorfman Disease (RDD) Mimicking Primary Cutaneous Marginal Zone B-cell Lymphoma.
- Author:
Tai Kyung NOH
1
;
Kwang Hee WON
;
Do Young RHEE
;
Chong Hyun WON
;
Sung Eun CHANG
;
Mi Woo LEE
;
Jee Ho CHOI
;
Kee Chan MOON
Author Information
1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. miumiu@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Rosai-Dorfman disease;
Sinus histiocytosis with massive lymphadenopathy
- MeSH:
Biopsy;
Dermis;
Diagnosis;
Female;
Histiocytes;
Histiocytosis, Sinus*;
Humans;
Isotretinoin;
Lymph Nodes;
Lymphocytes;
Lymphoma, B-Cell, Marginal Zone*;
Middle Aged;
Prednisolone;
Radiotherapy;
S100 Proteins
- From:Korean Journal of Dermatology
2013;51(10):809-813
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is an idiopathic, benign, histiocytic proliferative disease involving lymph nodes and extranodal sites. A 52-year-old woman presented with a 2-year history of multiple non-tender, erythematous nodules on her face. The initial punch biopsy showed lymphoid follicle-like aggregation of CD20 positive lymphocytes in the papillary dermis consisting of primary cutaneous marginal zone B-cell lymphoma. She underwent a 3-month course of radiotherapy, but the lesions progressed. The re-biopsy specimen revealed marked histiocytes with positive CD68 and S-100 proteins. The patient was treated with prednisolone and isotretinoin to which she responded slightly. Repeated histopathologic examinations enable us to make a definite diagnosis. Differentiating these two disorders as early as possible is crucial for appropriate treatment.
