Fully Implantable Deep Brain Stimulation System with Wireless Power Transmission for Long-term Use in Rodent Models of Parkinson's Disease.
10.3340/jkns.2015.57.3.152
- Author:
Man Seung HEO
1
;
Hyun Seok MOON
;
Hee Chan KIM
;
Hyung Woo PARK
;
Young Hoon LIM
;
Sun Ha PAEK
Author Information
1. Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Implantable system;
Deep-brain stimulation;
Wearable wireless power transfer
- MeSH:
Animals;
Deep Brain Stimulation*;
Electric Stimulation;
Electrodes;
Neural Prostheses;
Parkinson Disease*;
Rodentia*
- From:Journal of Korean Neurosurgical Society
2015;57(3):152-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of this study to develop new deep-brain stimulation system for long-term use in animals, in order to develop a variety of neural prostheses. METHODS: Our system has two distinguished features, which are the fully implanted system having wearable wireless power transfer and ability to change the parameter of stimulus parameter. It is useful for obtaining a variety of data from a long-term experiment. RESULTS: To validate our system, we performed pre-clinical test in Parkinson's disease-rat models for 4 weeks. Through the in vivo test, we observed the possibility of not only long-term implantation and stability, but also free movement of animals. We confirmed that the electrical stimulation neither caused any side effect nor damaged the electrodes. CONCLUSION: We proved possibility of our system to conduct the long-term pre-clinical test in variety of parameter, which is available for development of neural prostheses.
