Therapeutic Experience of Bing-Neel Syndrome Associated with Waldenstrom's Macroglobulinemia.
10.3346/jkms.2007.22.6.1079
- Author:
Hyun Do KIM
1
;
Kyeong Cheol SHIN
;
Hee Soon CHO
;
Min Kyoung KIM
;
Kyung Hee LEE
;
Myung Soo HYUN
Author Information
1. Department of Internal Medicine, Yeoungnam University College of Medicine, Daegu, Korea. hms@medical.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Waldenstrom's Macroglobulinemia;
Central Nervous System
- MeSH:
Antibodies, Monoclonal/therapeutic use;
Brain/pathology;
Central Nervous System Diseases/etiology/*therapy;
Cranial Irradiation;
Female;
Humans;
Middle Aged;
Syndrome;
Vidarabine/analogs & derivatives/therapeutic use;
Waldenstrom Macroglobulinemia/*complications
- From:Journal of Korean Medical Science
2007;22(6):1079-1081
- CountryRepublic of Korea
- Language:English
-
Abstract:
Waldenstrom's macroglobulinemia is an uncommon low-grade B-cell lymphoproliferative disorder in which monoclonal immunoglobulin M is produced. Neurological symptoms due to hyperviscosity are frequent manifestations of Waldenstrom's macroglobulinemia. However, central nervous system infiltration by plasmacytoid lymphocytes (Bing-Neel syndrome) has only rarely been reported. We report a case of a 51-yr-old woman suffering from Waldenstrom's macroglobulinemia who complained of persistant headache. Brain magnetic resonance imaging revealed an extra-axial soft tissue mass along the left cavernous sinus, left tentorium, right tentorium, and falx cerebri. A stereotactic biopsy of dural tissue from the falx was performed and showed plasmacytoid lymphocyte infiltration. The patient became symptom- free with irradiation of the whole brain followed by chemotherapy with fludarabine.
