Two Cases of Generalized Pustular Psoriasis Improved with Combination Treatment of Mycophenolate Mofetil.
- Author:
Yun Hwan JANG
1
;
Won Chae LEE
;
Gun Yeon NA
;
Seok Jong LEE
;
Do Won KIM
Author Information
1. Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea. nagy@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Mycophenolate mofetil;
Generalized pustular psoriasis;
Immunosuppressant
- MeSH:
Acitretin;
Cyclosporine;
DNA;
Guanine Nucleotides;
Humans;
Immunosuppressive Agents;
Lymphocytes;
Psoriasis*;
RNA
- From:Korean Journal of Dermatology
2003;41(12):1644-1649
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mycophenolate mofetil(MMF) is a new immunosuppressant which non-competitively and reversibly blocks the de novo synthesis of guanine nucleotides required for DNA and RNA synthesis during lymphocyte proliferation. So MMF selectively inhibits lymphocyte proliferation and it has less side-effects than other immunosuppressants. We described 2 cases of generalized pustular psoriasis improved with MMF. We administered MMF combined with cyclosporin in case 1 and acitretin in case 2. Both patients markedly improved with MMF administration 3 days after and had no severe side-effects. Thus the authors thought that MMF appears to be an effective therapeutic alternative in the treatment of generalized pustular psoriasis.
