Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection.
- Author:
Chang Seok BANG
1
;
Yeon Soo KIM
;
Sang Hyun PARK
;
Jin Bong KIM
;
Gwang Ho BAIK
;
Ki Tae SUK
;
Jai Hoon YOON
;
Dong Joon KIM
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords: Helicobacter pylori; Pronase
- MeSH: Adult; Amoxicillin/therapeutic use; Anti-Bacterial Agents/*therapeutic use; Clarithromycin/therapeutic use; Drug Administration Schedule; Drug Therapy, Combination/methods; Female; Gastric Mucosa/drug effects/microbiology; Helicobacter Infections/*drug therapy; Helicobacter pylori/*drug effects; Humans; Male; Middle Aged; Pronase/*therapeutic use; Prospective Studies; Proton Pump Inhibitors/*therapeutic use; Single-Blind Method; Treatment Outcome
- From:Gut and Liver 2015;9(3):340-345
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication. METHODS: This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE). RESULTS: In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups. CONCLUSIONS: According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (ClinicalTrial.gov: NCT01645761).
