Cytokine Expression of Microscopic Colitis Including Interleukin-17.
- Author:
Eunkyoung PARK
1
;
Young Sook PARK
;
Dae Rim PARK
;
Sung Ae JUNG
;
Dong Soo HAN
;
Byung Ik JANG
;
Young Ho KIM
;
Won Ho KIM
;
Yun Ju JO
;
Ki Ho LEE
;
Won Mi LEE
;
Eun Kyung KIM
;
Hae Soo KOO
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Colitis, collagenous; Immunohistochemistry; Colitis, lymphocytic; Colitis, microscopic
- MeSH: Biopsy; Colitis, Microscopic/*metabolism; Colon/pathology; Cyclooxygenase 2/*metabolism; Cytokines/metabolism; Diarrhea/metabolism; Humans; Interferon-gamma/metabolism; Interleukin-17/*metabolism; Intestinal Mucosa/pathology; NF-kappa B/metabolism; Nitric Oxide Synthase Type II/*metabolism; Tumor Necrosis Factor-alpha/metabolism
- From:Gut and Liver 2015;9(3):381-387
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis. METHODS: This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappaB, interferon-gamma, inducible nitric oxide synthase, and tumor necrosis factor-alpha. We compared the quantity score of immunohistochemical staining among the groups. RESULTS: The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappaB, and interferon-gamma compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis. CONCLUSIONS: Proinflammatory cytokines, including interleukin-17 and interferon-gamma, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients.
