Intraneural Perineurioma in the Tongue: A Case Report.
- Author:
Jun KANG
1
;
Shin Kwang KHANG
;
Jene CHOI
;
Jeong Won KIM
;
Eul Ju SEO
;
Bu kyu LEE
;
Eunsil YU
Author Information
1. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. esyu@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Nerve sheath neoplasms;
Tongue neoplasms;
Immunohistochemistry;
In situ hybridization, Fluorescence;
Genes, Neurofibromatosis 2
- MeSH:
Adolescent;
Chromosomes, Human, Pair 22;
Genes, Neurofibromatosis 2;
Humans;
Immunohistochemistry;
In Situ Hybridization, Fluorescence;
Male;
Mucous Membrane;
Nerve Sheath Neoplasms*;
Onions;
Peripheral Nerves;
S100 Proteins;
Schwann Cells;
Tongue Neoplasms;
Tongue*
- From:Korean Journal of Pathology
2007;41(1):51-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of an intraneural perineurioma that developed in an unusual location, the tongue. A 16-year-old male presented with a 1 cm sized protruding submucosal mass in his tongue without any sensory or motor signs or symptoms. The mass was excised. The mucosa was intact, with an ill-defined firm mass measuring 1.0 x 0.8 x 0.6 cm in the submucosa and muscle. The cut surface of the mass was pinkish gray and fibrotic. Microscopically, the mass contained tortuous and thickened peripheral nerve bundles in the submucosa, showing onion bulb like structures. The onion bulb like structures consisted of centrally located S-100 protein positive Schwann cells surrounded by Glut-1 positive perineurial cells. The FISH study did not reveal any genetic aberrations in chromosome 22.
