Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy.
- Author:
Dong Kyu LEE
1
;
Sang Woong HAN
;
Seung Sam PAIK
;
Moon Hyang PARK
;
Jong Un LEE
;
Ho Jung KIM
Author Information
1. Department of Internal Medicine, Hanyang University, Guri Hospital, Guri, Korea. kimhj@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Adriamycin;
Laminin beta1;
Proteinuria;
Renin-angiotensin system;
Tubulointerstitial lesion
- MeSH:
Angiotensin II;
Animals;
Blood Pressure;
Cilazapril;
Doxorubicin;
Humans;
Laminin;
Losartan;
Male;
Proteinuria;
Rats;
Rats, Sprague-Dawley;
Renin-Angiotensin System*
- From:Korean Journal of Nephrology
2005;24(1):26-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy. METHODS: Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2 mg/kg). After 6 weeks, rats showing heavy proteinuria were orally treated with either cilazapril 1 mg/kg/day (ACEi group, n=7) or losartan 10 mg/kg/day (ARB group, n=7) during the period of additional 6 weeks. The other group was maintained without any drugs (ADR group, n=6). The control group was without adriamycin treatment and maintained during the 12 weeks (Control, n=5). RESULTS: Systolic blood pressure was increased following the adriamycin treatment, which was normalized by treatment with cilazapril or losartan. Accordingly, cilazapril and losartan normalized the 24-h urine protein/creatinine ratio, in association with morphologic improvement of tubulointerstitial lesions. The expression of laminin beta1 was not altered in any experimental groups. CONCLUSION: These results suggest that angiotensin II plays an important role in tubulointerstitial lesions in adriamycin-induced nephropathy.
