Percutaneous Pericardiostomy and Trastuzumab Monotherapy for Treating Pericardial Metastasis from Breast Cancer and this Presented as Cardiac Tamponade.
- Author:
Hyeong Gon MOON
1
;
Eun Jung JUNG
;
Soon Tae PARK
;
Dae Hyun SONG
;
Woo Song HA
;
Sang Kyung CHOI
;
Soon Chan HONG
;
Young Joon LEE
;
Young Tae JOO
;
Chi Young JEONG
Author Information
1. Department of Surgery, School of Medicine, Gyeongsang National University Hospital, Jinju, Korea. stpark@nongae.gsnu.ac.kr
- Publication Type:Case Report
- Keywords:
Breast cancer;
Malignant pericardial effusion;
Trastuzumab;
Pericardiostomy;
Cardiac tamponade
- MeSH:
Antibodies, Monoclonal, Humanized;
Autopsy;
Breast;
Breast Neoplasms;
Cardiac Tamponade;
Decompression;
Follow-Up Studies;
Humans;
Neoplasm Metastasis;
Pericardial Effusion;
Pericardial Window Techniques;
Pericardiocentesis;
Recurrence;
Stress, Psychological;
Trastuzumab
- From:Journal of the Korean Surgical Society
2008;75(2):129-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although autopsy studies suggest that malignant pericardial effusion is present in up to 15% of the patients suffering with malignancies, symptomatic pericardial effusion presenting as a first manifestation of systemic recurrence in a breast cancer patient is a rare condition. Symptomatic malignant pericardial effusion requires prompt attention and intervention since it can lead to the cardiac tamponade. Treatment of symptomatic pericardial effusion includes pericardial decompression and systemic or intrapericardial chemotherapy. We recently experienced a patient with early breast cancer who developed cardiac tamponade from malignant pericardial effusion as a first manifestation of systemic recurrence 4 years after her initial surgery. The patient was treated with percutaneous pericardiocentesis and she subsequently received systemic trastuzumab. After 6 cycles of trastuzumab, the follow-up CT showed complete disappearance of the pericardial effusion and the mediastinal lymph nodes.
