A Studyof Dermal Mast Cells Number in End Stage of Renal Failure.
- Author:
Yong Dae KIM
;
Kyu Suk LEE
;
Joon Young SONG
;
Hyun Chul KIM
- Publication Type:Original Article
- Keywords:
Hemodialysis;
Mast cell;
Renal failure
- MeSH:
Biopsy;
Histamine;
Humans;
Mast Cells*;
Parathyroid Hormone;
Pruritus;
Radioimmunoassay;
Renal Dialysis;
Renal Insufficiency*;
Skin
- From:Korean Journal of Dermatology
1988;26(6):785-790
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We studied the relationship between dermal mast cell proliferation and pruritus in patients with end stage of renal failure. Skin biopsies were taken from 21 patients undergoing hemodialysis in end stage of renal failure. As a control, 12 pruritic patients without any internai problem were u.d. During the hemodialysis, 13 patient ha<) pruritus. Serum PTH levels were measured by radioimmunoassay. We have thought that the cause of pruritus in patients undergoing hemodialysis is related with dermal mast cell proliferation and a release of histamine. The results were as follows .' 1. Significantly larger numbers of dermal mast cells were found in hemodialysis patients than in the control (p<0.001). 2. Significantly larger mumbers of dermal mast cells were found in prnritic patients than in the non pruritic patients among hemodialysis patients (p<0.01). 3. There was no clear relationship between dermal mast cell proliferation and duration of hemodialysis or seum level of parathyroid hormone.
