A Study on the Effect of Various Dosage of Khellin on Epidermal Melanocytes and a Comparison with Trimethylpsoralen in Systemic Photochemotherapy.
- Author:
Moon Soo YOON
;
Kyung Tai HONG
;
Yoon Kee PARK
- Publication Type:Original Article
- Keywords:
Khellin;
Me]anocyte;
TMP
- MeSH:
Animals;
Biopsy;
Dihydroxyphenylalanine;
Khellin*;
Melanocytes*;
Mice;
Photochemotherapy*;
Phototherapy;
Skin;
Thymidine Monophosphate;
Trioxsalen*
- From:Korean Journal of Dermatology
1988;26(6):828-838
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ninety black C 57 BL mice were divided into control and photochemotherapy groups. Control group was subdivided into a UVA 1rradiation only subgroup and a khellin only administration subgroup, while the phototherapy group was subdivided into one TMP and two khellin administration subgroups with dosages of 1.5mg/kg, 5mg/kg and 20mg/kg, respectivly. UVA was administered three thimes a week in a dose of 4J/cm for 4 weeks. Skin biopsies were taken at 0, l, 2, 3 and 4 weeks and the split DOPA stain was employed to observe pigment production. The number, size and circumference of the melanocytes were assessed. In summary, our results inclicate that khellin, which is slightly less effective than TMP at the same effective dose, is quite effective for pigment production and the degree of the production is dose related.
