MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection.
- Author:
Dakeun LEE
1
;
Young Chul KIM
;
Kee Myung LEE
;
Joon Kee YOON
;
Young Bae KIM
Author Information
- Publication Type:Case Report
- Keywords: Early gastric cancer; MET amplification; Metastasis
- MeSH: Adenocarcinoma; Aged; Female; Fluorescence; Follow-Up Studies; Gene Amplification; Humans; In Situ Hybridization; Lymph Nodes; Mucous Membrane; Neoplasm Metastasis; Stomach Neoplasms*; Surgical Procedures, Minimally Invasive
- From:Cancer Research and Treatment 2015;47(1):120-125
- CountryRepublic of Korea
- Language:English
- Abstract: Intramucosal gastric cancer (IGC) is associated with a very low risk of lymph node metastasis; thus it is the main candidate for minimally invasive surgical procedures, such as endoscopic submucosal dissection (ESD). Herein, we document an extraordinary case of IGC, which showed a very aggressive clinical course. A 66-year-old female underwent ESD for early gastric cancer. Histologically, the tumor consisted mainly of moderately differentiated adenocarcinoma measuring 1.6 cm in diameter, and the tumor was confined to the mucosa. Despite annual esophagogastroduodenoscopic follow-up, the tumor recurred, with wide metastasis to multiple lymph nodes and bones throughout the body after three years. Fluorescence in situ hybridization study demonstrated MET gene amplification as well as low grade polysomy 7 in both original and recurrent tumors. The clinical characteristics of metastatic IGCs and the implication of MET amplification are discussed.
