Results of Combined Chemotherapy and Radiotherapy for Advanced Intraocular Retinoblastoma.
- Author:
In Young CHUNG
1
;
Eon Jeong KIM
;
Jong Moon PARK
;
Ji Myong YOO
Author Information
1. Department of Ophthalmology, Gyeongsang National University College of Medicine, Korea. YJM@nongae.gsnu.ac.kr
- Publication Type:Original Article
- MeSH:
Carboplatin;
Classification;
Drug Therapy*;
Etoposide;
Follow-Up Studies;
Humans;
Light Coagulation;
Nimustine;
Radiotherapy*;
Recurrence;
Retinoblastoma*;
Retrospective Studies;
Vincristine
- From:Journal of the Korean Ophthalmological Society
2003;44(7):1528-1537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report the result of combined chemotherapy and radiotherapy for 5 retinoblastoma patients. METHODS: Retrospective study of 5 patients (8 eyes) who were diagnosed with retinoblastoma of group III to V in the Reese-Ellsworth (R-E) classification was done. After 6 cycles of chemotherapy consisting of Vincristine, VP-16 (Etoposide) and Carboplatin, Radiotherapy (4500Gy/5weeks) was done. Neoaedjuvant therapy consisting of Nimustine and Carboplatin was done, and supplementary laser photocoagulation was done in 1 case. Mean follow-up period is 33 months. RESULTS: Significant reduction of tumor size and regression were observed in five eyes of R-E classification group V, and slight reduction of tumor size and regression were observed in three eyes of R-E classification groups III and IV. There was no recurrence and no new mass was detected. CONCLUSIONS: Combined chemotherapy, radiotherapy and supplementary therapy may save eyeballs which were diagnosed with retinoblastoma, even R-E classification group V.
