Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing.
10.5999/aps.2014.41.6.638
- Author:
Elijah Zhengyang CAI
1
;
Erin Yiling TEO
;
Lim JING
;
Yun Pei KOH
;
Tan Si QIAN
;
Feng WEN
;
James Wai Kit LEE
;
Eileen Chor Hoong HING
;
Yan Lin YAP
;
Hanjing LEE
;
Chuen Neng LEE
;
Swee Hin TEOH
;
Jane LIM
;
Thiam Chye LIM
Author Information
1. Department of Surgery, National University Health System, Singapore.
- Publication Type:Original Article
- Keywords:
Skin;
Wounds;
Hyaluronic acid;
Polycaprolactone;
Rabbit
- MeSH:
Bandages*;
Granulation Tissue;
Hyaluronic Acid;
Inflammation;
Membranes*;
Pelvic Bones;
Rabbits;
Re-Epithelialization;
Regeneration;
Ribs;
Skin;
Wound Healing;
Wounds and Injuries*
- From:Archives of Plastic Surgery
2014;41(6):638-646
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. METHODS: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0x3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. RESULTS: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. CONCLUSIONS: BPM is comparable to Mepitel as a safe and efficacious wound dressing.
