Endoscopic Ultrasonography-Guided Ethanol Ablation for Small Pancreatic Neuroendocrine Tumors: Results of a Pilot Study.
- Author:
Do Hyun PARK
1
;
Jun Ho CHOI
;
Dongwook OH
;
Sang Soo LEE
;
Dong Wan SEO
;
Sung Koo LEE
;
Myung Hwan KIM
Author Information
- Publication Type:Original Article
- Keywords: Endosonography; Ethanol; Ablation; Neuroendocrine tumors
- MeSH: Diagnosis; Endosonography; Ethanol*; Follow-Up Studies; Humans; Insulinoma; Neuroendocrine Tumors*; Pancreatitis; Pilot Projects*; Prospective Studies; Retrospective Studies
- From:Clinical Endoscopy 2015;48(2):158-164
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Endoscopic ultrasonography (EUS)-guided ethanol ablation is gaining popularity for the treatment of focal pancreatic lesions. The aim of this study was to evaluate the safety, feasibility, and treatment response after EUS-guided ethanol injection for small pancreatic neuroendocrine tumors (p-NETs). METHODS: This was a retrospective analysis of a prospectively collected database including 11 consecutive patients with p-NETs who underwent EUS-guided ethanol injection. RESULTS: EUS-guided ethanol injection was successfully performed in 11 patients with 14 tumors. The final diagnosis was based on histology and clinical signs as follows: 10 non-functioning neuroendocrine tumors and four insulinomas. During follow-up (median, 370 days; range, 152 to 730 days), 10 patients underwent clinical follow-up after treatment, and one patient was excluded because of loss to follow-up. A single treatment session with an injection of 0.5 to 3.8 mL of ethanol resulted in complete responses (CRs) at the 3-month radiologic imaging for seven of 13 tumors (response rate, 53.8%). Multiple treatment sessions performed in three tumors with residual viable enhancing tissue increased the number of tumors with CRs to eight of 13 (response rate, 61.5%). Mild pancreatitis occurred in three of 11 patients. CONCLUSIONS: EUS-guided ethanol injection appears to be a safe, feasible, and potentially effective method for treating small p-NETs in patients who are poor surgical candidates.
