Long-term Effectiveness and Tolerability of Topiramate in Children with Epilepsy under the Age of 2 Years: 4-Year Follow-up.
10.3346/jkms.2009.24.6.1078
- Author:
Jung Mi KIM
1
;
Soonhak KWON
;
Hye Eun SEO
;
Byung Ho CHOE
;
Min Hyun CHO
;
Sung Pa PARK
Author Information
1. Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea. shkwon@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Topiramate;
Carbamazepine;
Treatment Outcome;
Adverse Effects
- MeSH:
Anticonvulsants/adverse effects/*therapeutic use;
Carbamazepine/adverse effects/therapeutic use;
Child;
Child, Preschool;
Epilepsy/*drug therapy;
Female;
Follow-Up Studies;
Fructose/adverse effects/*analogs & derivatives/therapeutic use;
Humans;
Infant;
Male;
Treatment Outcome
- From:Journal of Korean Medical Science
2009;24(6):1078-1082
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is a long-term, open label, observational study aimed to broaden our clinical experiences in managing infants and toddlers with epilepsy. The long-term retention rate and side effects of topiramate (TPM) in them were evaluated and compared with carbamazepine (CBZ). A total of 146 children were involved in the study (TPM=41, CBZ=105). The retention rates at 24 , 36, and 48 months were 46.3%, 34.1%, 26.8% for TPM and 36.2%, 23.8%, 13.3% for CBZ, respectively. At 6 months after starting antiepileptic drugs (AED), the seizure freedom or clinical efficacy (seizure reduction rate more than 50 percent) were 73.2% for TPM and 62.9% for CBZ. The major side effects led to discontinuation included psychomotor slowing, poor oral intake from TPM and sleepiness and skin rash from CBZ. TPM was discontinued due to side effects in one case (2.4%) and lack of efficacy in five cases (12.2%), whereas CBZ was discontinued due to lack of efficacy (22.9%) and side effects (6.7%). As compared with CBZ, TPM showed the same long-term retention rate in children under the age of 2 yr, and no serious side effects. It is therefore concluded that TPM can be considered as a major AED for treating children with epilepsy under the age of 2 yr.
