Diagnostic Efficacy of PET/CT Plus Brain MR Imaging for Detection of Extrathoracic Metastases in Patients with Lung Adenocarcinoma.
10.3346/jkms.2009.24.6.1132
- Author:
Ho Yun LEE
1
;
Kyung Soo LEE
;
Byung Tae KIM
;
Young Seok CHO
;
Eun Jeong LEE
;
Chin A YI
;
Myung Jin CHUNG
;
Tae Sung KIM
;
O Jung KWON
;
Hojoong KIM
Author Information
1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kyungs.lee@samsung.com
- Publication Type:Original Article
- Keywords:
PET/CT Scan;
Lung Neoplasms;
Neoplasm Metastasis;
Brain;
Magnetic Resonance Imaging;
Neoplasm Staging
- MeSH:
*Adenocarcinoma/diagnosis/pathology/radiography;
Adult;
Aged;
Aged, 80 and over;
*Carcinoma, Non-Small-Cell Lung/diagnosis/pathology/radiography;
Female;
Humans;
*Lung Neoplasms/diagnosis/pathology/radiography;
Magnetic Resonance Imaging;
Male;
Middle Aged;
*Neoplasm Metastasis;
Positron-Emission Tomography/*methods;
ROC Curve;
Sensitivity and Specificity;
Tomography, X-Ray Computed/*methods;
Young Adult
- From:Journal of Korean Medical Science
2009;24(6):1132-1138
- CountryRepublic of Korea
- Language:English
-
Abstract:
We aimed to evaluate prospectively the efficacy of positron emission tomography (PET)/computed tomography (CT) plus brain magnetic resonance imaging (MRI) for detecting extrathoracic metastases in lung adenocarcinoma. Metastatic evaluations were feasible for 442 consecutive patients (M:F=238:204; mean age, 54 yr) with a lung adenocarcinoma who underwent PET/CT (CT, without IV contrast medium injection) plus contrast-enhanced brain MRI. The presence of metastases in the brain was evaluated by assessing brain MRI or PET/CT, and in other organs by PET/CT. Diagnostic efficacies for metastasis detection with PET/CT plus brain MRI and with PET/CT only were calculated on a per-patient basis and compared from each other. Of 442 patients, 88 (20%, including 50 [11.3%] with brain metastasis) had metastasis. Regarding sensitivity of overall extrathoracic metastasis detection, a significant difference was found between PET/CT and PET/CT plus brain MRI (68% vs. 84%; P=0.03). As for brain metastasis detection sensitivity, brain MRI was significantly higher than PET/CT (88% vs. 24%; P<0.001). By adding MRI to PET/CT, brain metastases were detected in additional 32 (7% of 442 patients) patients. In lung adenocarcinoma patients, significant increase in sensitivity can be achieved for detecting extrathoracic metastases by adding dedicated brain MRI to PET/CT and thus enhancing brain metastasis detection.
