Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants.
10.3345/kjp.2017.60.8.248
- Author:
Birgul SAY
1
;
Nurdan URAS
;
Suzan SAHIN
;
Halil DEGIRMENCIOGLU
;
Serife Suna OGUZ
;
Fuat Emre CANPOLAT
Author Information
1. Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. birgullivasay@gmail.com
- Publication Type:Original Article
- Keywords:
Early onset sepsis;
Cord vitamin D level;
Late onset sepsis;
Preterm infants
- MeSH:
Communicable Diseases;
Fetal Blood*;
Gestational Age;
Humans;
Infant;
Infant, Newborn;
Infant, Premature*;
Sepsis*;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:Korean Journal of Pediatrics
2017;60(8):248-253
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants. METHODS: One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration ≥5 ng/mL and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration ≥15 ng/mL. RESULTS: Sixty-three percent of the infants had deficient levels of cord blood vitamin D (group 1), 24% had insufficient levels (group 2), and 13% were found to have sufficient levels (group 3). The rate of neonatal sepsis was higher in group 2 than in groups 1 and 3. CONCLUSION: There was no significant relationship between the cord blood vitamin D levels and the risk of neonatal sepsis in premature infants.
