Shear Wave Elastography for Detection of Prostate Cancer: A Preliminary Study.
10.3348/kjr.2014.15.3.346
- Author:
Sungmin WOO
1
;
Sang Youn KIM
;
Jeong Yeon CHO
;
Seung Hyup KIM
Author Information
1. Department of Radiology, Seoul National University Hospital, Seoul 110-744, Korea. iwishluv@empas.com
- Publication Type:Original Article
- Keywords:
Prostate cancer;
Shear wave elastography;
Young modulus;
Ultrasonography;
Gleason score
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Biopsy;
Elasticity Imaging Techniques/*methods;
Humans;
Male;
Middle Aged;
Neoplasm Grading;
Prostate/pathology/*ultrasonography;
Prostate-Specific Antigen/blood;
Prostatic Neoplasms/pathology/*ultrasonography;
ROC Curve;
Retrospective Studies;
Sensitivity and Specificity;
Ultrasonography, Interventional/methods
- From:Korean Journal of Radiology
2014;15(3):346-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To assess the diagnostic value of shear wave elastography (SWE) for prostate cancer detection. MATERIALS AND METHODS: In this retrospective study, 87 patients with the suspicion of prostate cancer (prostate-specific antigen > 4 ng/mL and abnormal digital rectal examination) underwent a protocol-based systematic 12-core biopsy followed by targeted biopsy at hypoechoic areas on grey-scale ultrasound. Prior to biopsy, SWE was performed by placing two circular 5 mm-sized regions of interest (ROIs) along the estimated biopsy tract in each sector and one ROI for hypoechoic lesions. SWE parameters, S (mean stiffness) and R (mean stiffness ratio), were calculated and compared regarding different histopathologic tissues and their accuracy for diagnosing prostate cancer was analyzed. SWE parameters were correlated with Gleason score and were compared between indolent (< 8) and aggressive (> or = 8) tissues in prostate cancer patients. RESULTS: Prostate cancer was detected in 7.5% of 1058 cores in 29.9% of 87 patients. Seven (43.8%) of 16 hypoechoic lesions were confirmed as prostate cancer. SWE parameters were significantly different among the histopathologic entities (p < 0.001). Prostate cancer was stiffer than benign tissues (p < or = 0.003). Sensitivity, specificity and receiver operating characteristic curve area for diagnosing cancer were 43%, 80.8%, and 0.599, respectively, for a cutoff of S > 43.9 kPa and 60.8%, 66.4%, and 0.653, respectively, for R > 3. Both, S and R showed a significant correlation with Gleason score (r > or = 0.296, p < or = 0.008) and were significantly different between indolent and aggressive prostate cancer (p < or = 0.006). CONCLUSION: Shear wave elastographic parameters are significantly different between prostate cancer and benign prostate tissue and correlate with Gleason score.
