Computer-Aided Classification of Visual Ventilation Patterns in Patients with Chronic Obstructive Pulmonary Disease at Two-Phase Xenon-Enhanced CT.
10.3348/kjr.2014.15.3.386
- Author:
Soon Ho YOON
1
;
Jin Mo GOO
;
Julip JUNG
;
Helen HONG
;
Eun Ah PARK
;
Chang Hyun LEE
;
Youkyung LEE
;
Kwang Nam JIN
;
Ji Yung CHOO
;
Nyoung Keun LEE
Author Information
1. Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 110-744, Korea. jmgoo@plaza.snu.ac.kr
- Publication Type:Original Article ; Evaluation Studies ; Validation Studies
- Keywords:
Computer-aided classification;
Computed tomography;
Chronic obstructive pulmonary disease;
Regional ventilation;
Xenon CT
- MeSH:
Aged;
Area Under Curve;
Feasibility Studies;
Female;
Humans;
Male;
Middle Aged;
Observer Variation;
Pulmonary Disease, Chronic Obstructive/physiopathology/*radiography;
Pulmonary Emphysema/physiopathology/radiography;
*Respiration;
Retrospective Studies;
Tomography, X-Ray Computed/*methods;
Xenon/*diagnostic use
- From:Korean Journal of Radiology
2014;15(3):386-396
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the technical feasibility, performance, and interobserver agreement of a computer-aided classification (CAC) system for regional ventilation at two-phase xenon-enhanced CT in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Thirty-eight patients with COPD underwent two-phase xenon ventilation CT with resulting wash-in (WI) and wash-out (WO) xenon images. The regional ventilation in structural abnormalities was visually categorized into four patterns by consensus of two experienced radiologists who compared the xenon attenuation of structural abnormalities with that of adjacent normal parenchyma in the WI and WO images, and it served as the reference. Two series of image datasets of structural abnormalities were randomly extracted for optimization and validation. The proportion of agreement on a per-lesion basis and receiver operating characteristics on a per-pixel basis between CAC and reference were analyzed for optimization. Thereafter, six readers independently categorized the regional ventilation in structural abnormalities in the validation set without and with a CAC map. Interobserver agreement was also compared between assessments without and with CAC maps using multirater kappa statistics. RESULTS: Computer-aided classification maps were successfully generated in 31 patients (81.5%). The proportion of agreement and the average area under the curve of optimized CAC maps were 94% (75/80) and 0.994, respectively. Multirater kappa value was improved from moderate (kappa = 0.59; 95% confidence interval [CI], 0.56-0.62) at the initial assessment to excellent (kappa = 0.82; 95% CI, 0.79-0.85) with the CAC map. CONCLUSION: Our proposed CAC system demonstrated the potential for regional ventilation pattern analysis and enhanced interobserver agreement on visual classification of regional ventilation.
