Neuropsychological Functioning and Dimensions of Symptoms in Schizophrenia.
- Author:
Hyun Sang CHO
1
;
Yeon Hee LEE
;
Ki Hyun KIM
;
Sang Woo YOO
;
Hee Sang LEE
;
Kae Joon YOO
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea. chs0225@hitel.net
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Neuropsychological function;
Dimensions of symptoms
- MeSH:
Brain;
Confounding Factors (Epidemiology);
Diagnosis;
Gyrus Cinguli;
Neuropsychological Tests;
Parietal Lobe;
Positron-Emission Tomography;
Rabeprazole;
Schizophrenia*
- From:Korean Journal of Psychopharmacology
1998;9(2):169-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: On the basis of the relationship between positron emission tomography and symptom profiles in schizophrenia by Liddle et al, the authors attempted to investigate the related brain regions associated with clinical symptoms by studying the correlations between the performance of neuro-psychological tests likely to reflect functioning of dorsolateral preftontal, orbitofiontal or cingulate, parietal, and temporal cortices and 3 dimensions (psychotic or reality distortion, negative, and disorganization) of symptoms. METHODS: 41 subjects with a confirmed diagnosis of schizophrenia were scored for each of the three dimensions by Positive and Negative Syndrome Scale. Subjects performed 12 neuropsychological tests designed to measure impairment in specific areas of the brain. RESULTS: According to partial co-rrelations to remove possible confounding variables, the neuropsychological correlates of psychotic(reality distortion) and disorganization dimensions were some tests considered to be related to dorsolateral prefrontal and parietal lobes, and cingulate and dorsolateral preliontal cortices, respectively. CONCLUSION: The results support a part of hypotheses, a specific relation between disorganization and cingulate cortex. In addition our results suggest the possibile relations between a psychotic dimension and functions of dorsolateral prefrontal and parietal lobes, and between a disorganization one and functions of cingulate and dorsolateral prefrontal cortices. The authors believe that our study supports different neural circuits associated with each of dimensions of symptoms, particularly psychotic and disorganization, in schizophrenia.
