Two Cases of Acute Renal Failure Associated with Aprotinin.
- Author:
Yeong Seop YUN
1
;
Soon Hyo KWON
;
Eun kyung PARK
;
Jin Seok JEON
;
Hyun Jin NOH
;
Dong Cheol HAN
;
So Young JIN
Author Information
1. Department of Internal Medicine, College of Medicine, Soon Chun Hyang University, Seoul, Korea. jeonjs@hosp.sch.ac.kr
- Publication Type:Case Report
- Keywords:
Aprotinin;
Acute renal failure
- MeSH:
Acute Kidney Injury;
Aprotinin;
Arteries;
Arterioles;
Biopsy;
Female;
Hemorrhage;
Humans;
Infarction;
Obstetric Surgical Procedures;
Perioperative Period;
Serine Proteases
- From:Korean Journal of Nephrology
2008;27(3):383-388
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Aprotinin is a nonspecific serine protease inhibitor and antifibrinolytic agent. It has been used to control bleeding and reduce the amounts of transfusion during the perioperative period. There are few reports on adverse effects following aprotinin use. However, several reports have been recently published, suggesting an increased risk for renal events or deaths in patients given aprotinin. We report two cases of ARF associated with aprotinin. To reduce perioperative blood loss, aprotinin was administered to two patients who underwent obstetrical surgeries in which ARF subsequently developed. Renal biopsies displayed microthrombi within the arterioles and small arteries, causing infarctions and collapses of glomeruli. Although renal functions were not completely recovered, the two patients are now being followed up without dialysis
