Clinical manifestations for diabetes mellitus in HIV-infected Koreans on highly active antiretroviral therapy.
- Author:
Heekyoung CHOI
1
;
Su Jin JEONG
;
Han Sung LEE
;
Bum Sik CHIN
;
Suk Hoon CHOI
;
Sang Hoon HAN
;
Myung Soo KIM
;
Chang Oh KIM
;
Jun Yong CHOI
;
Young Goo SONG
;
June Myung KIM
Author Information
1. Department of Internal Medicine, Yonsei University Colleges of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
HIV;
Acquired immunodeficiency syndrome;
Diabetes mellitus;
Antiretroviral therapy
- MeSH:
Acquired Immunodeficiency Syndrome;
Antiretroviral Therapy, Highly Active;
Case-Control Studies;
Cohort Studies;
Diabetes Mellitus;
Fasting;
Follow-Up Studies;
Glucose;
HIV;
HIV Infections;
Humans;
Incidence;
Indinavir;
Insulin Resistance;
Protease Inhibitors;
Retrospective Studies;
Risk Factors;
Viral Load
- From:Korean Journal of Medicine
2008;74(5):506-514
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV infection. However, the HAART regimens, and especially those including protease inhibitors (PIs), have been shown to cause diabetes mellitus. We evaluated the incidence and clinical manifestations of HIV-infected Koreans who received HAART and the risk factors for diabetes mellitus in those patients. METHODS: We conducted a retrospective cohort study and a case-control study to evaluate the clinical manifestations, the incidence and the risk factors for diabetes mellitus in 215 HIV-infected patients who were on HAART at Yonsei University College of Medicine from 1991 to 2006. RESULTS: 215 patients were analyzed and the total duration of follow up was 1079 person-years. The incidences of diabetes mellitus and impaired fasting glucose were 1.39 case/100person-years and 6.02 case/100person-years. Most of the cases were non-obese type II diabetes and these patients showed insulin resistance and impaired beta cell function. On the risk factor analysis, the factors contributing to the development of diabetes were age, a decrease of the viral load and indinavir use. CONCLUSIONS: In our study, the incidence of diabetes among Korean HIV-positive patients on HAART was 1.39case/100person-years. Age, a decrease of the viral load and indinavir use were the risk factors for development of diabetes mellitus.
