Clinical Usefulness of TrepanostikaTM, Enzyme-Linked Immunosorbent Assay for Detection of Treponema pallidum-Specific Antibody.
- Author:
Young Ah KIM
1
;
Dong Hee CHO
;
Hyon Suk KIM
Author Information
1. Department of Clinical Pathology, College of Medicine, Yonsei University.
- Publication Type:Original Article
- Keywords:
Treponema pallidum-specific antibody;
Enzyme-linked immunosorbent assay (ELISA);
Syphilis
- MeSH:
Absorption;
Enzyme-Linked Immunosorbent Assay*;
Hemagglutination;
Humans;
Sensitivity and Specificity;
Syphilis;
Treponema pallidum;
Treponema*
- From:Korean Journal of Clinical Pathology
1998;18(2):255-258
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The TrepanostikaTM is an enzyme-linked immunosorbent assay (ELISA) for the qualitative determination of specific antibody (Ab) to Treponema pallidum. It is important to detect Treponema pallidum-specific Ab to confirm syphilis in patients with positive nontreponemal result or at late latent stage/late stage. Currently various ELISA methods for Treponema pallidum- specific Ab have been developed in addition to widely used treponemal tests such as fluorescent treponemal antibody absorption (FTA-ABS) test or Treponema pallidum hemagglutination (TPHA) test. We evaluated TrepanostikaTM, anti-treponemal ELISA test. METHODS: The sensitivity and specificity of this ELISA method for detecting Treponema pallidum- specific Ab (TrepanostikaTM) were evaluated and compared with other treponemal tests such as FTA-ABS and TPHA. RESULTS: The sensitivity and specificity of TrepanostikaTM were 95.7% and 95.8%, respectively. The concordance rate with FTA-ABS was 98.9% (283/286) and 100% (272/272) with TPHA. CONCLUSIONS: TrepanostikaTM which has similar sensitivity and specificity with FTA-ABS or TPHA could replace the well-known treponemal test such as FTA-ABS or TPHA.
