The Effect of intraperitoneal instillation of Mistletoe extract during the diagnostic laparoscopy for pain of endometriosis.
- Author:
So Yi RIM
1
;
Sung Taek OH
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Chonnam National University, Gwangju, Korea. ohst@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Endometriosis;
Pelvic pain;
Mistltoe extract
- MeSH:
Ambulatory Care Facilities;
Endometriosis*;
Female;
Gonadotropin-Releasing Hormone;
Histamine Antagonists;
Humans;
Laparoscopy*;
Mistletoe*;
Pelvic Pain
- From:Korean Journal of Obstetrics and Gynecology
2005;48(4):1004-1008
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Immune alternation is related to the pathogenesis and progression of endometriosis. Helixor-A, mistletoe extract, has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the effects of Helixor-A for pain of endometriosis by intraperitoneal instillation of mistletoe extract during the diagnostic laparoscopy. METHODS: Among the paitients who visited to outpatient clinic due to chronic pelvic pain, 30 patients who had laparoscopically-confirmed endometriosis were included in this study. Helixor-A 5 mg was instilled into the posterior cul-de-sac during the diagnostic laparoscopy. Before diagnostic laparoscopy and one month after laparoscopy, the patients recorded pain scores. RESULTS: In 11 of 30 patients (36.7%), pelvic pain of endometriosis improved after laparoscopy. In 2 of 30 patients, the side-effect of Helixor- A appeared and they were easily controlled by antihistamines. CONCLUSION: The instillation of Helixor-A during diagnostic laparoscopy, that is essential for confirmation of endometriosis, may be helpful as a supportive treatment for treatment of pelvic pain due to endometriosis with classical treatment such as GnRH agonist therapy.
