Factors influencing pregnancy rates in intrauterine insemination.
- Author:
Yeon Kyoung KIM
1
;
Dong Myung SHIN
;
Do Gyun KIM
;
Hoe Saeng YANG
Author Information
1. Department of Obstetrics and Gynecology, Dongguk University College of Medicine, Kyong-ju, Korea. ykkim76@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Intrauterine insemination;
Age;
Treatment cycles;
Preovulatory follicles;
Motile sperm
- MeSH:
Clomiphene;
Gonadotropins;
Gyeongsangbuk-do;
Humans;
Infertility;
Insemination*;
Logistic Models;
Odds Ratio;
Pregnancy Rate*;
Pregnancy*;
Retrospective Studies;
Sperm Count
- From:Korean Journal of Obstetrics and Gynecology
2005;48(4):1009-1016
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We have studied the factors that influence the pregnancy rate in ovarian hyperstimulation and intrauterine insemination (IUI) in infertility patients. METHODS: Seventy two patients who visited the infertility clinic in Dongguk University Kyong-ju hospital from January 2002 to December 2003 underwent IUI after 99 cycles of ovarian hyperstimulation. We administered clomiphene with exogenous gonadotropin from cycle day 3 and then IUI was performed. The variables selected for retrospective analysis were patient's age (<35 years), duration (<6 years) and type (primary or secondary) and etiology of infertility, number of treatment cycles (>or=2), number of follicles (>or=2), size of dominant follicle (>or=18 mm), total sperm counts (>or=10 X 10(6)). Chi-square test, Fisher's exact test and a multiple logistic regression analysis were used to detect differences between groups in each variable. RESULTS: The pregnancy rate per patient was 29.2% (21/72) and 21.2% (21/99) per cycle. Factors that influenced pregnancy rate were age, number of treatment cycles, number of preovulatory follicles (>or=16 mm), and total inseminated motile sperm counts, all of which showed significant differences (p<0.05). Multiple logistic regression analysis identified significant predictors as age (<35 vs. >or=35), number of treatment cycles (2 cycle vs. 1 cycle), number of preovulatory follicles (>or=16 mm) (>or=3 vs. 1), and total inseminated motile sperm counts (>or=40 X 10(6) vs. <10 X 10(6)). The odds ratio of each of these variables were 12.6, 3.37, 11.64, and 10.59. CONCLUSION: For successful pregnancy rates in IUI after ovarian hyperstimulation, the patient's age, number of treatment cycles, number of preovulatory follicles, and total inseminated motile sperm counts should be considered.
