An Analysis of p53, bcl-2 and Ki-67 Expressions, and Apoptosis in Rectal Cancer: Their Correlation with the Tumor Response after Preoperative Radiochemotherapy.
- Author:
Jinyoung YOO
1
;
Su Zy KIM
;
Hyeon Min CHO
;
Sung Whan KIM
;
Hyung Min CHIN
;
Jung Yong LEE
;
Jun Ki KIM
;
Seok Jin KANG
;
Chung Soo CHUN
;
Chang Suk KANG
Author Information
1. Departments of Pathology, The Catholic University of Korea College of Medicine, Seoul 442-723, Korea. sjkang@vincent.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Rectal neoplasms;
Protein, p53;
bcl-2 protein antigen;
Ki-67 protein antigen;
Apoptosis
- MeSH:
Apoptosis*;
Biopsy;
Chemoradiotherapy*;
Humans;
Immunohistochemistry;
Rectal Neoplasms*;
Recurrence
- From:Korean Journal of Pathology
2005;39(4):222-228
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Background : Preoperative radiochemotherapy (RCT) has been administered for locally advanced rectal cancer to increase the therapeutic benefits, and to preserve the sphincter in low-lying tumors, however, tumor responses after RCT are variable. Methods : Apoptotic index (AI), and expressions of Ki-67, p53 and bcl-2 were analyzed in pretreatment biopsies from 69 patients with rectal cancer by immunohistochemistry. Tumor response was graded in surgically resected specimens by using a three-scale grading system: no response (NR), partial remission (PR) and complete remission (CR). Results : CR was identified in 19 cases (28%), PR in 24 cases (35%), and NR in 26 cases (38%) of 69 cases. p53 protein was expressed in 49 cases (71%), whereas bcl-2 was in 42 cases (61%). The pretreatment Ki-67 labeling index was 65.4+/-3.4%. The tumor response was not associated with any of these markers. Tumors with CR/PR showed a higher AI (0.84+/-.84%/0.66+/-.52%) than that of tumors with NR (0.58+/-0.54%). There was a significant correlation between tumor response and the histologic differentiation (p=0.008) or recurrence (p=0.039). Conclusions : The AI revealed a tendency to increase in tumors with CR/PR, while expressions of p53 and bcl-2, and Ki-67 labeling index had little direct association with tumor response.
