Prevalence and risk factors of gallstones in a general health screened population.
- Author:
Yun Jin CHUNG
1
;
Young Dae PARK
;
Ho Chul LEE
;
Han Jin CHO
;
Kwan Sik PARK
;
Eun Hee SEO
;
Seung Woo JEON
;
Chang Min CHO
;
Won Young TAK
;
Young Oh KWEON
;
Sung Kook KIM
;
Yong Hwan CHOI
;
Jong Seub KIM
;
Hyun Jung LEE
;
Joon Mo CHUNG
Author Information
1. Department of Internal Medicine, Kyungpook National University, School of Medicine, Kyungpook National University Hospital, Daegu, Korea. cmcho@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Gallstone;
Prevalence;
Risk factor;
Metabolic syndrome
- MeSH:
Aspartate Aminotransferases;
Biliary Tract;
Blood Glucose;
Body Mass Index;
Cholesterol;
Fasting;
Female;
Gallbladder;
Gallstones*;
Gyeongsangbuk-do;
Health Promotion;
Health Surveys;
Humans;
Korea;
Liver Function Tests;
Logistic Models;
Male;
Mass Screening;
Prevalence*;
Risk Factors*;
Triglycerides;
Ultrasonography
- From:Korean Journal of Medicine
2007;72(5):480-490
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Gallstone is the most common disease of the biliary system. Most cases of gallstone are asymptomatic and we incidentally found gallstones during a community health survey. Our study was designed to determine the prevalence and risk factors for gallstone in a population who underwent health screening. METHODS: We enrolled a total of 36,314 persons who visited the health promotion center in Kyungpook National University Hospital in Korea from 1998 to 2004. They had their gallbladder or biliary system examined with using ultrasonography. The body mass index and biochemical parameters from liver function tests, the lipid profiles and the fasting blood sugar were all measured. All the subjects were divided into several groups and the particular prevalence for gallstone disease for each group was calculated. Chi-square tests and logistic regression analysis assessed the risk factors for gallstone disease. RESULTS: Among 36,314 persons, (19,345 males (53.3%) and 16,969 females (46.7%)), gallstone was found in 735 persons (2.0%). On univariate analysis, the risk factors for gallstone disease were age, body mass index, fasting blood sugar, total cholesterol, LDL-cholesterol, triglyceride and serum aspartate aminotransferase. On multivariate logistic regression analysis, the the risk factors were high body mass index, older age and high fasting blood sugar. CONCLUSIONS: The risk factors seem to show a common pathogenesis for gallstone disease. Although the relation between gallstone disease and metabolic syndrome has not been established, it appears to be associated with metabolic syndrome, but further study on a general population is required.
