Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model.
- Author:
Goeun YANG
1
;
Dongsun PARK
;
Sun Hee LEE
;
Dae Kwon BAE
;
Yun Hui YANG
;
Jangbeen KYUNG
;
Dajeong KIM
;
Ehn Kyoung CHOI
;
Jin Tae HONG
;
Heon Sang JEONG
;
Hee Jung KIM
;
Su Kil JANG
;
Seong Soo JOO
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea. solar93@cbu.ac.kr
- Publication Type:Original Article
- Keywords:
Ischemic brain injury;
Middle cerebral artery occlusion;
Glial fibrillary acidic protein;
Rosa hybrida;
Antioxidation;
Anti-inflammation
- MeSH:
Animals;
Brain;
Brain Injuries;
Cyclooxygenase 2;
Glial Fibrillary Acidic Protein;
Humans;
Infarction;
Infarction, Middle Cerebral Artery*;
Male;
Malondialdehyde;
Middle Cerebral Artery*;
Neuroprotective Agents*;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Rats;
Reperfusion;
Rosa*;
Stroke
- From:Biomolecules & Therapeutics
2013;21(6):454-461
- CountryRepublic of Korea
- Language:English
-
Abstract:
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
