Developmental Changes of Membrane Proteins from Human Erythrocytes.
- Author:
Chan Uhng JOO
1
;
Hyun Suk LEE
;
Jung Soo KIM
;
Kyu Cha KIM
;
Hyung Rho KIM
Author Information
1. Department of Pediatrics, Jeonbug National University Medical School, Korea.
- Publication Type:Original Article
- Keywords:
Membrane Proteins;
Human Erythrocytes
- MeSH:
Adenosine Triphosphatases;
Adult;
Carrier Proteins;
Cholinesterases;
Erythrocyte Membrane;
Erythrocytes*;
Fetal Blood;
Glucose;
Glycoproteins;
Humans*;
Membrane Proteins*;
Membranes*;
Phosphoric Monoester Hydrolases
- From:Journal of the Korean Pediatric Society
1982;25(6):541-546
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was lower than that of fetal erythrocyte membranes, whereas adult cholinesterase was higher. No significant change was observed in the activities of alkaline and acid phosphatases during development. 3. Glucose uptake was higher in fetal erythrocytes than in adult erythrocytes, suggesting some loss of glucose carrier system during devlopment. The results suggest that the major structural proteins in human erythrocyte membrane relatively unchanged while some functional proteins such as membrane enzymes and carrier proteins in transport systems are markedly changed during development.
