Interaction of Rifampin and Warfarin.
10.4046/trd.1999.47.6.768
- Author:
Yeon Mok OH
1
Author Information
1. Department of Internal Medicine, Boochun Sejong Hospital, Boochun, Korea. change52@medikorea.net
- Publication Type:Original Article
- Keywords:
rifampin;
warfarin;
interaction
- MeSH:
Appointments and Schedules;
Cerebral Hemorrhage;
Cytochrome P-450 Enzyme System;
Healthy Volunteers;
Heart Diseases;
Humans;
Intracranial Embolism;
Prothrombin;
Prothrombin Time;
Rifampin*;
Tuberculosis;
Warfarin*
- From:Tuberculosis and Respiratory Diseases
1999;47(6):768-774
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It is well known that rifampin decreases the hypoprothrombinemic effect of warfarin by induction of cytochrome p-450 enzyme in healthy volunteer. However, in patients the dosage schedule o f warfarin during rifampin therapy is not established. Therefore, patients taking both rifampin and warfarin were reviewed to find out the adequate dosage schedule of warfafin in addition to side effects by interaction of two drugs. METHOD: Patients taking both rifampin and warfarin were retrieved from patients who were admitted due to heart disease and tuberculosis at Boochun Sejong Hospital from January of 1995 to August of 1999. To decide the adequate dosage of warfarin, the dosage of warfarin before, during, and after rifampin was evaluated in patients who kept adequate hypoprothrombinemic effect of warfarin during rifampin. To decide the adequate dosage schedule of warfarin, the time interval from the beginning of rifampin to normalization of prothrombin time(INR
