Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study.
10.4055/cios.2013.5.3.216
- Author:
Dae Geun JEON
1
;
Won Seok SONG
;
Chang Bae KONG
;
Wan Hyeong CHO
;
Sang Hyun CHO
;
Jeong Dong LEE
;
Soo Yong LEE
Author Information
1. Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea. dgjeon@kcch.re.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Osteosarcoma;
Local recurrence;
Surgical margin
- MeSH:
Adolescent;
Bone Neoplasms/*pathology/radiography/*surgery;
Case-Control Studies;
Chi-Square Distribution;
Female;
Humans;
Male;
Neoplasm Recurrence, Local/*pathology;
Neoplasm, Residual/pathology;
Osteosarcoma/*pathology/radiography/*surgery
- From:Clinics in Orthopedic Surgery
2013;5(3):216-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The relationship between surgical margin and local recurrence (LR) in osteosarcoma patients with poor responses to chemotherapy is unclear. Moreover, the incidences of LR according to three different resection planes (bone, soft tissue, and perineurovascular) are not commonly known. METHODS: We evaluated the incidence of LR in three areas. To assess whether there is a role of surgical margin on LR in patients resistant to preoperative chemotherapy, we designed a case (35 patients with LR) and control (70 patients without LR) study. Controls were matched for age, location, initial tumor volume, and tumor volume change during preoperative chemotherapy. RESULTS: LR occurred at the soft tissues in 18 cases (51.4%), at the perineurovascular tissues in 11 cases (31.4%), and at the bones in six cases (17.2%). The proportion of inadequate perineurovascular margin was higher in the case group than in the control group (p = 0.01). Within case-control group (105 patients), a correlation between each margin status and LR at corresponding area was found in the bone (p < 0.001) and perineurovascular area (p = 0.001). CONCLUSIONS: LR is most common in soft tissues. In patients showing similar unfavorable responses to chemotherapy, the losses of perineurovascular fat plane on preoperative magnetic resonance imaging may be a valuable finding in predicting LR.
