Elevated red cell distribution width is associated with advanced fibrosis in NAFLD.
10.3350/cmh.2013.19.3.258
- Author:
Hwa Mok KIM
1
;
Bum Soo KIM
;
Yong Kyun CHO
;
Byung Ik KIM
;
Chong Il SOHN
;
Woo Kyu JEON
;
Hong Joo KIM
;
Dong Il PARK
;
Jung Ho PARK
;
Kwan Joong JOO
;
Chang Joon KIM
;
Yong Sung KIM
;
Woon Je HEO
;
Won Seok CHOI
Author Information
1. Division of Gastroenterology and Hepatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Choyk2004.cho@samsung.com
- Publication Type:Original Article
- Keywords:
Red-blood-cell distribution width;
Nonalcoholic fatty liver disease;
BARD score;
FIB-4 score
- MeSH:
Adult;
Alcohol Drinking;
C-Reactive Protein/analysis;
Diabetes Mellitus/pathology;
Erythrocyte Indices;
Fatty Liver/complications/*diagnosis/ultrasonography;
Female;
Humans;
Hypertension/pathology;
Liver Cirrhosis/*diagnosis/epidemiology/etiology;
Male;
Middle Aged;
Odds Ratio;
Prevalence;
Questionnaires;
Severity of Illness Index
- From:Clinical and Molecular Hepatology
2013;19(3):258-265
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The red-blood-cell distribution width (RDW) is a newly recognized risk marker in patients with cardiovascular disease, but its role in nonalcoholic fatty liver disease (NAFLD) has not been well defined. The aim of the present study was to determine the association between RDW values and the level of fibrosis in NAFLD according to BARD and FIB-4 scores. METHODS: This study included 24,547 subjects who had been diagnosed with NAFLD based on abdominal ultrasonography and questionnaires about alcohol consumption. The degree of liver fibrosis was determined according to BARD and FIB-4 scores. The association between RDW values and the degree of fibrosis in NAFLD was analyzed retrospectively. RESULTS: After adjusting for age, hemoglobin level, mean corpuscular volume, history of hypertension, history of diabetes, and high-sensitivity C-reactive protein, the RDW values were 12.61+/-0.41% (mean+/-SD), 12.70+/-0.70%, 12.77+/-0.62%, 12.87+/-0.82%, and 13.25+/-0.90% for those with BARD scores of 0, 1, 2, 3, and 4, respectively, and 12.71+/-0.72%, 12.79+/-0.66%, and 13.23+/-1.52% for those with FIB-4 scores of <1.30, 1.31-2.66, and > or =2.67, respectively (P<0.05). The prevalence of advanced fibrosis (BARD score of 24 and FIB-4 score of > or =1.3) increased with the RDW [BARD score: 51.1% in quartile 1 (Q1) vs. 63.6% in Q4; FIB-4 score: 6.9% in Q1 vs. 10.5% in Q4; P<0.001]. After adjustments, the odds ratio of having advanced fibrosis for those in Q4 compared to Q1 were 1.76 (95%CI=1.55-2.00, P<0.001) relative to BARD score and 1.69 (95%CI=1.52-1.98, P<0.001) relative to FIB-4 score. CONCLUSIONS: Elevated RDW is independently associated with advanced fibrosis in NAFLD.
