Protective Effect of Fisetin (3,7,3',4'-Tetrahydroxyflavone) against gamma-Irradiation-Induced Oxidative Stress and Cell Damage.
- Author:
Mei Jing PIAO
1
;
Ki Cheon KIM
;
Sungwook CHAE
;
Young Sam KEUM
;
Hye Sun KIM
;
Jin Won HYUN
Author Information
1. School of Medicine and Institute for Nuclear Science and Technology, Jeju National University, Jeju 690-756, Republic of Korea. jinwonh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Apoptosis;
Cell damage;
Fisetin;
gamma-irradiation;
Reactive oxygen species
- MeSH:
Antioxidants;
Apoptosis;
Cell Death;
DNA Damage;
Lipid Peroxidation;
Membrane Potential, Mitochondrial;
Membranes;
Oxidative Stress*;
Protein Carbonylation;
Radiation, Ionizing;
Reactive Oxygen Species
- From:Biomolecules & Therapeutics
2013;21(3):210-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether the antioxidant effects of the flavonoid fisetin (3,7,3',4'-tetrahydroxyflavone) included the radioprotection of cells exposed to gamma-irradiation. Fisetin reduced the levels of intracellular reactive oxygen species generated by gamma-irradiation and thereby protected cells against gamma-irradiation-induced membrane lipid peroxidation, DNA damage, and protein carbonylation. In addition, fisetin maintained the viability of irradiated cells by partially inhibiting gamma-irradiation-induced apoptosis and restoring mitochondrial membrane potential. These effects suggest that the cellular protective effects of fisetin against gamma-irradiation are mainly due to its inhibition of reactive oxygen species generation.
