Relationship between Vitamin D, Parathyroid Hormone, and Bone Mineral Density in Elderly Koreans.
10.3346/jkms.2012.27.6.636
- Author:
Guilsun KIM
1
;
Ki Won OH
;
Eun Hee JANG
;
Mee Kyoung KIM
;
Dong Jun LIM
;
Hyuk Sang KWON
;
Ki Hyun BAEK
;
Kun Ho YOON
;
Won Chul LEE
;
Bong Yun CHA
;
Kwang Woo LEE
;
Ho Young SON
;
Moo Il KANG
Author Information
1. Department of Internal Medicine, Division of Endocrinology and Metabolism, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. mikang@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Vitamin D;
Intact Parathyroid Hormone;
Bone Density;
Age;
Sex
- MeSH:
Absorptiometry, Photon;
Age Factors;
Aged;
*Bone Density;
Female;
Femur/anatomy & histology;
Humans;
Hyperparathyroidism/diagnosis/etiology;
Lumbosacral Region/anatomy & histology;
Male;
Middle Aged;
Parathyroid Hormone/*blood;
Postmenopause;
Republic of Korea;
Seasons;
Sex Factors;
Vitamin D/*analogs & derivatives/blood
- From:Journal of Korean Medical Science
2012;27(6):636-643
- CountryRepublic of Korea
- Language:English
-
Abstract:
There is controversy regarding definition of vitamin D inadequacy. We analyzed threshold 25-hydroxyvitamin D (25[OH]D) below which intact parathyroid hormone (iPTH) increases, and examined age- and sex-specific changes of 25(OH)D and iPTH, and association of 25(OH)D and iPTH with bone mineral density (BMD) in elderly Koreans. Anthropometric parameters, serum 25(OH)D and iPTH, lumbar spine and femur BMD by dual-energy radiography absorptiometry (DXA) were measured in 441 men and 598 postmenopausal women. iPTH increased below serum 25(OH) of 36.7 ng/mL in men, but failed to reach plateau in women. Femur neck BMD above and below threshold differed when threshold 25(OH)D concentrations were set at 15-27.5 ng/mL in men, and 12.5-20 ng/mL in postmenopausal women. Vitamin D-inadequate individuals older than 75 yr had higher iPTH than those aged < or = 65 yr. In winter, age-associated iPTH increase in women was steeper than in summer. In conclusion, vitamin D inadequacy threshold cannot be estimated based on iPTH alone, and but other factors concerning bone health should also be considered. Older people seemingly need higher 25(OH)D levels to offset age-associated hyperparathyroidism. Elderly vitamin D-inadequate women in the winter are most vulnerable to age-associated hyperparathyroidism.
