Association of Serum 25-Hydroxyvitamin D Levels with Markers for Metabolic Syndrome in the Elderly: A Repeated Measure Analysis.
10.3346/jkms.2012.27.6.653
- Author:
Hye Yin PARK
1
;
Youn Hee LIM
;
Jin Hee KIM
;
Sanghyuk BAE
;
Se Young OH
;
Yun Chul HONG
Author Information
1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. ychong1@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Vitamin D;
Insulin Resistance;
Metabolic Syndrome;
Elderly;
Mixed Effect Model
- MeSH:
Aged;
Aged, 80 and over;
Biological Markers/blood;
Blood Pressure;
Female;
Humans;
Hypertriglyceridemia/diagnosis/etiology;
Insulin/blood;
Insulin Resistance;
Male;
Metabolic Syndrome X/*diagnosis/etiology;
Middle Aged;
Odds Ratio;
Risk Factors;
Triglycerides/blood;
Vitamin D/*analogs & derivatives/blood;
Vitamin D Deficiency/complications
- From:Journal of Korean Medical Science
2012;27(6):653-660
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.
