Expression of Neuropeptides and Their Receptors in Psoriatic Lesions.
- Author:
Seung Seog HAN
1
;
Woo Jin YUN
;
Hae Jin JUNG
;
Sung Eun CHANG
;
Mi Woo LEE
;
Jee Ho CHOI
;
Kee Chan MOON
;
Jai Kyoung KOH
Author Information
1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Korea. han_newtype@hotmail.com
- Publication Type:Original Article
- Keywords:
Neuropeptide;
Neuropeptide receptor;
Psoriasis
- MeSH:
Biopsy;
Calcitonin Gene-Related Peptide;
Humans;
Microscopy, Confocal;
Neprilysin;
Neuropeptides*;
Psoriasis;
Receptors, Calcitonin Gene-Related Peptide;
Receptors, Neuropeptide;
Skin;
Somatostatin;
Substance P
- From:Korean Journal of Dermatology
2006;44(10):1191-1194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Neuroimmunocutaneous system alteration can be responsible for the induction and maintenance of the inflammatory process of psoriasis. OBJECTIVE: This study was carried out to examine the expression of Substance P (SP), calcitonin gene-related peptide (CGRP), somatostatin (SOM), neutral endopeptidase (NEP), SP receptor, and CGRP receptor in psoriatic lesions. METHODS: A skin biopsy was obtained from 10 psoriatic patients and 10 normal control subjects. Confocal laser scanning microscopy was performed. RESULTS: The SP and CGRP receptors consistently increased in psoriatic lesions, compared to the normal controls. CONCLUSION: The increased expression of neuropeptides and their receptors may be involved in the pathogenesis of psoriasis.
