Effect of Subconjunctival Injection of 5-Fluorouracil after Trabeculectomy.
- Author:
Yeon LEE
1
;
Moon Key LEE
Author Information
1. Department of Ophthalmology, Chonnam University, Medical School, Kwangju, Korea.
- Publication Type:Original Article
- MeSH:
Anterior Chamber;
Fibroblasts;
Fluorouracil*;
Follow-Up Studies;
Glaucoma;
Humans;
Hyperemia;
Hyphema;
Intraocular Pressure;
Postoperative Complications;
Prognosis;
Trabeculectomy*;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
1987;28(5):1027-1032
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
5-Fluorouracil(5-FU), an antimetabolite capable of inhibiting fibroblast proliferation, was administered subconjunctivally after trabeculectomy(with or without lens extraction) on 8 eyes of 8 patients with neovascular or aphakic glaucoma, with poor visual acuity and poor surgical prognosis. The follow-up period ranged from 4 to 12 months. The mean intraocular pressure was reduced by approximately 65.5%, from 45.3 mmHg preoperatively to 15.6 mmHg postoperatively. Four of 8 eyes required no medication, but 3 needed some topical medication to achieve an intraocular pressure of <21 mmHg, and the remainder was 24 mmHg with hypotensive medication, postoperatively. The postoperative visual acuities improved in 3 of 8 eyes and remained unchanged in 5. Postoperative complications were hyphema in 4 cases, delayed formation of anterior chamber in 1 case, and serious inflammatory reaction in anterior chamber and severe longstanding conjunctival hyperemia in all the cases.
