The Relationship between Serum Adiponectin, Essential Hypertension, LV Mass Index, and LV Diastolic Function.
10.4070/kcj.2003.33.12.1126
- Author:
Soon Jun HONG
1
;
Chang Gyu PARK
;
Jae Suk PARK
;
Jeong Cheon AHN
;
Sung Hee SHIN
;
Sung Mi PARK
;
Hong Euy LIM
;
Eung Joo KIM
;
Hong Seok SEO
;
Dong Joo OH
;
Young Moo RO
;
Yangsoo JANG
Author Information
1. Division of Cardiology, Korea University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Adiponectin;
Hypertension;
Left ventricular hypertrophy
- MeSH:
Adiponectin*;
Blood Pressure;
Body Mass Index;
Deceleration;
Humans;
Hypertension*;
Hypertrophy, Left Ventricular;
Plasma;
Relaxation
- From:Korean Circulation Journal
2003;33(12):1126-1133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Adiponectin is known for its anti-inflammatory and anti-atherogenic effects. The purpose of this study is to characterize the relationships among serum adiponectin, essential hypertension (EH), left ventricular mass index (LVMI), and LV diastolic function. SUBJECTS AND METHODS: Serum adiponectin by RIA and body mass index were measured in 275 patients (M: F=137: 138). We calculated LVMI, E/A ratio, deceleration time (DT), and isovolumetric relaxation time (IVRT) by using echocardiograms. RESULTS: The serum adiponectin level of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9+/-9.8 ug/mL vs. 12.9+/-9.5 ug/mL, p<0.05). Plasma adiponectin was negatively correlated with LVMI (r=-0.329, p<0.001), BMI (r=-0.290, p<0.001), and IVRT (r=-0.485, p<0.05), but was positively correlated with E/A (r=+0.359, p<0.001). CONCLUSION: These results suggest that a decrease in serum adiponectin is associated with an increase in blood pressure and BMI, progress of LVH, and decrease in LV diastolic function.
