Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury.
10.4062/biomolther.2014.103
- Author:
Yoon Ah SOHN
1
;
Seon A HWANG
;
Sun Yi LEE
;
In Young HWANG
;
Sun Whoe KIM
;
So Yeon KIM
;
Aree MOON
;
Yong Soo LEE
;
Young Ho KIM
;
Keum Jee KANG
;
Choon Sik JEONG
Author Information
1. College of Pharmacy, Duksung Women's University, Seoul 132-714, Republic of Korea. choonsik@duksung.ac.kr
- Publication Type:Original Article
- Keywords:
Liriodendrin;
Prostaglandin E2;
H+/K+-ATPase;
Gastritis;
Gastric ulcer
- MeSH:
Animals;
Colon;
Dinoprostone;
Gastric Acid;
Gastric Juice;
Gastritis;
Helicobacter pylori;
Hydrogen-Ion Concentration;
Kalopanax*;
Rats;
Stomach Neoplasms;
Stomach Ulcer
- From:Biomolecules & Therapeutics
2015;23(1):53-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 microM. It was also exhibited acid-neutralizing capacity (10.3%) and H+/K+-ATPase inhibition of 42.6% (500 microM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 +/- 2.14 ml), slightly higher pH (1.53 +/- 0.41), and smaller total acid output (0.47 +/- 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
