Comparison of Central Corneal Thickness after the Instillation of Topical Anesthetics: Proparacaine versus Oxybuprocaine.
- Author:
Kyoung Sub CHOI
1
;
Sang Min NAM
;
Hyung Keun LEE
;
Eung Kweon KIM
;
Kyoung Yul SEO
Author Information
1. The Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. seoky@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Central corneal thickness;
Oxybuprocaine;
Proparacaine
- MeSH:
Anesthetics*;
Humans
- From:Journal of the Korean Ophthalmological Society
2005;46(5):757-762
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare changes in human central corneal thickness after instillation of proparacaine with those after oxybuprocaine instillation, over a period of 10 minutes. METHODS: Eighteen healthy young participants were recruited. Baseline central corneal thicknesses were measured every 30 seconds for 10 minutes using a noncontact specular microscope. Changes in central corneal thickness were measured every 20 seconds for 10 minutes after the administration of one drop of 0.5% proparacaine into the right eye, and one drop of 0.4% oxybuprocaine into the left eye. RESULTS: Mean baseline central corneal thickness was 531 +/- 45 micrometer in the right eye and 531 +/- 42 micrometer in the left. The central corneal thickness after proparacaine instillation increased to 8.6 micrometer (4.5-12.6 micrometer, 95% CI) and then returned to baseline within 80 seconds. Central corneal thickness after oxybuprocaine instillation increased to 7.7 micrometer (3.6-11.2 micrometer, 95% CI) and then returned to baseline within 80 seconds. There was a second transient increase about 5 minute after proparacaine instillation but no additional transient increase after oxybuprocaine instillation. CONCLUSIONS: The severity of oxybuprocaine's effect on central corneal thickness is similar to that of proparacaine. Central corneal thickness instability may occur for 5 minutes after proparacaine administration. Therefore, changes in central corneal thickness after topical anesthetics instillation should be considered when measuring central corneal thickness.
